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KMID : 0895820140240010013
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Journal of Oriental Rehabilitation Medicine
2014 Volume.24 No. 1 p.13 ~ p.30
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The Effects of Bambusae caulis in liquamen and Bambusae concretio silicae on Blood Sugar Reduction and Improvement of Peripheral Nerve Function in Diabetic Rats Induced with Streptozotocin
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Park Soo-Gon
Bae Gil-Jun
Lee Ook-Jae
Kim Seon-Jong
Jung Min-Young
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Abstract
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Objectives : This study was designed to investigate the effects of Bambusae caulis in li-quamen and Bambusae concretio silicae on blood sugar reduction and improvement of pe-ripheral nerve function in diabetic rat models.
Methods : Diabetic rat models induced by streptozotocin were divided into five groups. We fed experimental group I of rats basal diet and administered normal saline (3 ml, 1 time/1 day) for 6 weeks. We fed experimental group II of rats basal diet and administered Bambusae caulis in liquamen (100 mg/kg, 1 time/1 day) for 6 weeks. We fed experimental group III, IV, V of rats basal diet and administered Bambusae concretio silicae (100 mg/kg, 200 mg/kg, 400 mg/kg once a day) for 6 weeks. We investigated weight and glucose level of rats, and carried out touch test, hot plate test, sensory ＆ motor nerve conduction veloc-ity test and immunohistochemical study after 48 hours, 2 weeks, 4 weeks and 6 weeks.
Results : 1. The weight of all experimental group was gradually decreased. And glucose level was significantly decreased in the experimental group II, III, IV, V as compared with ex-perimental group I. Especially experimental group II, IV, V were significantly decreased as compared with experimental group III. 2. In the quantitative analysis by touch test and hot plate test, mechanical pain threshold and heat pain threshold were significantly decreased in the other experimental groups as compared with experimental group I. Especially ex-perimental group II, IV, V were significantly decreased as compared with experimental group III. 3. In the sensory and motor nerve conduction velocity test, sensory and motor nerve con-duction velocity were significantly increased in the other experimental groups as compared with experimental group I. Especially experimental group II, IV, V were significantly increased as compared with experimental group III. 4. In the substance P immunohistochemical study, experimental group II, IV, V showed strong immune response in spinal cord.
Conclusions : Bambusae caulis in liquamen and Bambusae concretio silicae were prob-ably useful to treat patients with diabetic peripheral neuropathy.
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KEYWORD
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Bambusae caulis in liquamen, Bambusae concretio silicae, Diabetic periph-eral neuropathy, Peripheral nerve function
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